Passionflower

The medical utility of only a few species of Passiflora has been scientifically studied.[13] In initial study in 2001 for treatment of generalized anxiety disorder, maypop extract performed as well as oxazepam but with fewer short-term side effects.[14] It was recommended to follow up with long-term studies to confirm these results.

A study performed on mice demonstrated that Passiflora alata has a genotoxic effect on cells, and suggested further research was recommended before this one species is considered safe for human consumption.[15]

Passionflower herb (Passiflorae herba) from P. incarnata is listed in the European Pharmacopoeia. The herbal drug should contain not less than 1.5% total flavonoids expressed as vitexin.[citation needed]

Passionflower is reputed to have sedative effects and has been used in sedative products in Europe, but in 1978, the U.S. Food and Drug Administration prohibited its use in over-the-counter sedative preparations because it had not been proven safe and effective. In 2011, the University of Maryland Medical Center reported that passionflower "... can trigger side effects and can interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider."[16][17]

Passionflower is classified as generally recognized as safe (GRAS) for use in foods in the US,[18] and is “possibly safe when used orally and appropriately for short-term medicinal purposes,” “possibly unsafe when used in excessive amounts,” but unsafe when used orally during pregnancy since “...passionflower constituents show evidence of uterine stimulation.” The database suggests it is possibly effective for adjustment disorder with anxious mood, anxiety, and opiate withdrawal, but it “can cause dizziness, confusion, sedation, and ataxia” and there are some reports of more severe side effects including vasculitis and altered consciousness.

https://en.wikipedia.org/wiki/Passiflora